TU Berlin

Joint Lab BioelectronicsTheses

Ein rotes Dreieck, darunter drei orangen senkrechten Balken als Symbol für Fakultät 3. Das Symbol befindet sich innerhalb  des kreisförmigen Schriftzuges: Prozesswissenschaften.

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Theses

Currently, there is the possibility of writing a BSc or MSc thesis in the field of biotechnology with subjects mentioned under "Research". ( → module description). Based on the cooperation with Faculty IV, candidates from the field of electronics and computer science can also apply. Before a decision is made, we conduct interviews with interested parties about their previous knowledge and interests in order to identify strengths or areas in which potential can still be developed. The following topics are currently offered:

Electrical cell separation in microfluidic channels. The basic effect is dielectrophoresis. For life scientists, the question of its applicability to microalgae and other microorganisms to be investigated arises. From the point of view of electronics and computer science, on the other hand, it is of interest how the electrical cell properties can be determined or how the separation effect can be optimised using machine learning methods.

In-line process sensors. For the lab-of-the-future at the FGBVT, microsensors are being developed and tested that monitor the bioprocess in microtitre plates or minibioreactors. This includes sensors for the monitoring of biomass as well as metabolites. The principle of impedance measurement is used to measure biomass or cell density. For metabolites such as glucose we use special receptor assays such as ConcanavalinA-dextran.

Privacy for medical implants. Chemical sensors e.g. for glucose are on the verge of being used as full implants in medical diagnostics. This opens up completely new perspectives for the therapy of difficult diseases such as diabetes. But what about the privacy of the data obtained? How are the technical systems to be designed so that they meet the strict requirements of the DSGVO, which came into force last year? These questions were discussed in the lecture series "Internet and Privacy" and approaches to solutions are to be examined that are oriented to the development status of fitness trackers.

Electrically driven lysis of cells. In nucleic acid diagnostics, nucleotide strands to be examined must first be isolated from the cells. While detection and sequencing are now miniaturized, this is not yet the case with lysis. The aim of the work is to build a chip-based system that will allow the lysis process to be operated efficiently. At FG Sensorik und Aktuatorik an electronic system based on commercially available components is to be designed and built, and a "passive" chip with Au or TiN electrodes is to be controlled by this system. At FG BVT the system will be tested and protocols for different cell types will be studied to achieve maximum throughput and efficiency.

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