Groups involved

• Process Analytical Technology (PAT), Scale up & scale down
  

The project aims to systematically elucidate the influence of increasing bioreactor inhomogeneity, which occurs in industrial-scale bioreactor, with respect to microbial physiology and production performance of Corynebacterium glutamicum Such inhomogeneous conditions can be mimiced by a so called scale-down simulator bioreactor, consisting of a well-mixed stirred tank reactor (STR) and a plug-flow reactor (PFR) connected in series to it.

In order to follow impacts on population heterogeneity under oscillatory conditions, laser-based reflection sensor technology from S+E Sequip is adopted to realize a morphological analysis on a single-cell basis.

Partners (in Germany):

FZ Juelich (AG Prof. Oldiges), S+E Sequip

Links:

Programme ERA-IB 2